Pair Name	Cryptotanshinone, Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	GABPA	hsa2551
	Down-regulation	Expression	TK1	hsa7083
In Vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vivo Model	H1975 human lung cancer cells (5×10⁷ in 1 ml) or PC9/GR human lung cancer cells (3×10⁷ in 1 ml) were injected subcutaneously into the right flank of athymic BALB/c nude mice (3-4 weeks old).
Result	These findings indicated the role of TKT in lung cancer progression and may provide novel therapeutic strategies to overcome resistance to gefitinib. Furthermore, CTS may serve as a new candidate in adjuvant treatment of advanced lung cancer.